P2 – Establish a Panel of Respiratory and Reproducitive Parameters of Phthalate and Phytocannabinoid Exposures by Inhalation in Women and Men
Inhalation is a route of chemical exposure in domestic, occupational, recreational settings, as well as in both accidental and intentional scenarios. There is growing concern regarding the contribution of inhaled endocrine-disrupting compounds, including some plastic additives and phytocannabinoids, to adverse health effects. These compounds have been associated with respiratory diseases, infertility, and metabolic effects. However, their toxicokinetics and toxicological mechanisms are not well understood to improve chemical risk assessment and public health protection.
This study focuses on plastic additives, unintentionally inhaled through environmental and occupational exposure, and phytocannabinoids, which are inhaled recreationally or medically. Their distinct physicochemical properties and exposure contexts make them relevant models for assessing toxicological responses via inhalation. By analyzing biological fluids (blood, urine, and semen) from exposed volunteers, we aim to characterize the absorption, distribution, metabolism, and elimination of these compounds during short and long exposure time and determine their internal dose—the amount that enters the body and interacts with biological systems. Using an in vitroto in vivo extrapolation approach, we will investigate biological effects of selected plastic additives and phytocannabinoids on lung function, hormone regulation, fertility, and global biochemical phenotype to understand the mode of action.
This research will provide critical insights into inhalation toxicology, enhancing risk assessments and public health strategies to reduce harmful exposures to plastic additives and phytocannabinoids. It will also support regulatory agencies by contributing to national and international efforts in understanding the mechanisms driving adverse health effects.
Project Lead: Myriam Borgatta – Unisanté (Uni Lausanne)