Euro 2016 Hackathon on 24 - 25 October 2016: Case-driven Data Analysis. Euro 2016 Conference on 26 - 28 October 2016: Integrating Scientific Evidence supporting Risk Assessment and Safer Design of Novel Substances.

Emphasis will be specifically on how new technologies can strengthen the interpretation and application of in vitro methods in toxicological research and risk assessment. ESTIV 2016 congress is the ideal venue for reseach or industry toxicologists to meet and exchange scientific and regulatory information and knowledge. Young scientists are particularly encouraged to present their work and discuss results with senior scientists. 

Globally, Exposure Science is now recognized as a critical component for assessing and protecting human, environmental and ecological health. Scientists from more than 40 countries on six continents will come together at the ISES 2016 meeting in the Netherlands to exchange knowledge and information, to enhance the development of Exposure Sciences globally, to discuss, learn, and network.

The Congress major theme is “Toxicology and Global Sustainability”. This meeting will offer a forum for sharing basic and applied research in Toxicology and is aimed to convene international scientists to present their results related to the exposure to toxic agents, adverse effects, mechanisms of toxicity, preventive alternatives, normativity, etc, to strengthen the science-policy interface to foster the progress towards sustainability.

The 2 days training will give a comprehensive overview of the most relevant and robust 2D and 3D kidney cell culture models and in vitro tests applications for the assessment of kidney-associated cytotoxicity.

2D in vitro models to assess target organ toxicity potential of chemicals suffer from major limitations arising from lack of maintenance of physiological and chemical metabolism competence. 3D cell cultures have been receiving increasing attention as they permit the incorporation of 3D architecture, multiple cell types, flow and oxygen gradients, thereby better recapitulating an in vivo microenvironment. As these models have become more widely adopted, there has been corresponding improvements in high tissue-specific functionality, long-term viability, robustness, endpoint analysis, high-throughput screening and imaging analysis of these systems. This course will provide a review of different 3D microtissue and fluid-flow bioreactors used in toxicology and drug screening with a concise overview of the technologies, advantages and cost. Application examples of 3D cell-based systems to skin, heart and liver will be presented, in addition to a comparison of scaffold-free and scaffold-based methods. 

Drug safety in human patients is the ultimate goal of drug safety scientists. Because limitations of patient populations studied during drug development and uncertainties related to potential drug-drug interactions or rare or idiosyncratic adverse reactions, it is important to pay careful attention to human safety to achieve a better understanding of the safety of drugs on the market used in a wider patient population, for long treatment duration and on various co-medication compared to the population included in the approval package. Human safety plays an important role for assessing drug safety profile in daily conditions of use, which includes adherence to recommended modalities of therapeutic use (pharmacovigilance) as well as exposures deriving from accidental or intentional acute poisonings (clinical toxicology and toxicovigilance), misuse or abuse of therapeutic agents (pharmacodependence) or unintended indications. 

Key sessions for ETS 2016 will include: Education Course: Juvenile Toxicity Maternal Health in Pregnancy Developmental and Reproductive Toxicology: Regulatory Updates The Placenta Young Scientist Symposium

The Scientific Programme Committee has assembled an exciting and balanced programme where you can discuss and influence key advances in the science and practice of toxicology. In addition to presentation of cutting-edge research, the EUROTOX annual meetings offer an unparalleled venue for renewing professional relationships, for networking and for remaining up-to date in our challenging and expanding discipline.