In Part-2, more emphasis will be put on skin sensitization models such as h-clat (OECD TG 442E), DPRA (OECD TG 442C) or LuSens. The participants will also perform the IL/18 epiderm for identification and classification of skin sensitizing chemicals (MatTek) as well as the GARD skin sensitization test that detects potency (Senzagen).

In light of the limitations of existing non-animal based hazard assessment methodologies, particularly in the area of repeated dose as well as developmental and reproductive toxicity, readacross is currently considered to be the most applicable strategy in support of chemical’s hazard assessment. In this context, in silico tools play a critical role in identifying and justifying analogues suitable for the assessment of chemicals for which hazard data are lacking. This training co-organised with Toxminds is designed to give the necessary background along with tailored case studies to provide hands-on experience how in silico tools can be used in supporting a chemical’s hazard assessments: for example as stand-alone tools or for the identification and justification of analogues for use in read-across.  

The 2017 Scientific Program features a diverse range of scientific sessions organized into two themed tracks and covering issues such as Addressing Safety in Oncology, Translational Safety Pharmacology, Suicidality, New Modalities and New Biological Entities, Disease Models/Personalized Medicine, Microphysiological Systems - New Technologies, In Silico Modeling, Right Species-Right Time, Changing Regulatory Environment and more.

The goal of this workshop is to make attending scientists familiar with the design and conduct o typical in vitro experiments that are performed to profile the hepatic disposition characteristics of new drug candidates and/or xenobiotics. Focus will be on sound protocols for generating high quality in vitro data that can subsequently be used as input in physiologically-based pharmacokinetic (PBPK) models.

The 13th [BC]2 - the Basel Computational Biology Conference - is the key computational biology event in Switzerland in 2017 uniting scientists working in a broad range of disciplines, including bioinformatics, computational biology, neuroscience, medicine, and systems biology. Participation at [BC]2 will be the opportunity to learn about cutting-edge research in computational biology and bioinformatics.

Theme of this 53rd Congress of the European Societies of Toxicology is "Connecting for a Safer Future". The Scientific Programme Committee is preparing a programme with over 30 symposia and workshops that will highlight the novel findings in the field of toxicology. Four Poster Sessions and five Continuing Education Courses will offer a wide range of opportunities to enhance and enrich the professional experience.

Includes a 2 day extensive hands-on training on how to use a panel of standardized stable human- and yeast reporter cell lines for rapid screening of hazards of pure chemicals and complex mixtures on multiple adverse outcome pathways. This includes those pathways prioritized in the current regulatory context of EDC assessment, including interference with estrogen-, androgen-, and thyroid hormone signaling. This will include assessment of metabolic conversions (S9, metabolically competent liver cells - BIOPREDIC ) of EDCs using various approaches and assessment of their effects on steroidogenesis.

The quality control of meat and meat products encompasses a wide scope of different analytical techniques and analytical endpoints. Besides classical topics such as veterinary drugs, dioxins and PCBs, new topics such as the production of edible insects and vegetable based meat substitutes are emerging. The invited plenary speakers will provide an update on the science of the selected topics, with emphasis on progress in analytical techniques and strategies to detect various contaminants (e.g. veterinary drug residues, environmental contaminants), possible adulterants of meat, as well as additives.

In this one-week, hands-on workshop, leading modelling experts will introduce state-of-the-art and emerging modelling approaches and tools for all aspects of rational drug design and lead group work sessions, in which these tools will be applied on practical examples and case studies. Main topics covered by the workshop are: virtual screening, ligand-based and structure-based drug design, bio- and cheminformatics, molecular dynamics simulation, drug delivery modelling, systems biology and biotech drug design.